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AbstractFull Text

This study investigates in silico the genetic diversity of CSN2 on its evolutionary and differentiation within and among species and also examines the attendant effects of polymorphism on the functionality of CSN2. A total of 22 CNS2 gene sequences with corresponding amino acids belonging to 8...

Author(s)
Vincent, S. T.; Momoh, O. M.; Yakubu, A.
Publisher
KPK Publishers, Peshawar, Pakistan
Citation
Research Opinions in Animal and Veterinary Sciences, 2014, 4, 10, pp 564-570
Abstract

Motivation: Evolutionary conservation of DNA sequences provides a tool for the identification of functional elements in genomes. We have created a database of evolutionary conserved regions (ECRs) in vertebrate genomes, entitled ECRbase, which is constructed from a collection of whole-genome...

Author(s)
Loots, G.; Ovcharenko, I.
Publisher
Oxford University Press, Oxford, UK
Citation
Bioinformatics, 2007, 23, 1, pp 122-124
Abstract

Background: A number of vertebrate highly conserved elements (HCEs) have been detected and their genomic interval distances have been reported to be more conserved than protein coding genes among mammalian genomes. A characteristic of the human - non-mammalian comparisons is a bimodal distribution...

Author(s)
Sun Hong; Skogerbø, G.; Zheng XiaoHui; Liu Wei; Li YiXue
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2009, 10, 133, pp (27 March 2009)
Abstract

Tumour necrosis factor (TNF)-α is an important human cytokine that imparts dualism in malaria pathogenicity. At high dosages, TNF-α is believed to provoke pathogenicity in cerebral malaria; while at lower dosages TNF-α is protective against severe human malaria. To understand the human TNF-α gene...

Author(s)
Gauri Awasthi; Suchita Singh; Dash, A. P.; Aparup Das
Publisher
Contexto, Bahia, Brazil
Citation
Brazilian Journal of Infectious Diseases, 2008, 12, 5, pp 374-379
Abstract

We describe a whole-genome comparative analysis of the human, mouse, and rat genomes to describe the average substitution patterns of four genomic regions: ancient repeats, rodent-specific DNA, exons, and conserved (coding and noncoding) regions, and to identify rodent evolutionary hotspots. In all ...

Author(s)
Yap, V. B.; Pachter, L.
Publisher
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, USA
Citation
Genome Research, 2004, 14, 4, pp 574-579
Abstract

Completion of the Rattus norvegicus genome sequence enabled a global inventory and analysis of the nuclear receptors (NRs) in three mammalian species. Forty-nine NR members were found in mouse, 48 in human. Forty-seven were found in the rat, with gaps at the locations expected for the other two....

Author(s)
Zhang, Z. D.; Burch, P. E.; Cooney, A. J.; Lanz, R. B.; Pereira, F. A.; Wu, J. Q.; Gibbs, R. A.; Weinstock, G.; Wheeler, D. A.
Publisher
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, USA
Citation
Genome Research, 2004, 14, 4, pp 580-590
Abstract

Betaretroviruses exist in endogenous and exogenous forms in hosts that are widely distributed and evolutionarily distantly related. Here we report the discovery and characterization of several previously unknown betaretrovirus groups in the genomes of Mus musculus and Rattus norvegicus. Each group...

Author(s)
Baillie, G. J.; Lagemaat, L. N. van de; Baust, C.; Mager, D. L.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Journal of Virology, 2004, 78, 11, pp 5784-5798
Abstract

Rattus norvegicus is an important experimental organism and interesting to evolutionary biologists. The recently published d raft rat genome sequence provides us with insights into both the rat's evolution and its physiology. We learn more about genome evolution and, in particular, the adaptive...

Author(s)
Hancock, J. M.
Publisher
John Wiley and Sons, Inc, New York, USA
Citation
BioEssays, 2004, 26, 10, pp 1039-1042
Abstract

BSP proteins represent three major proteins of bovine seminal plasma: BSP-A1/-A2, -A3 and -30 kDa. The BSP protein signature is characterized by two tandemly repeated fibronectin type 2 (Fn2) domains. Although classical affinity chromatography and protein sequencing have proven that the BSP protein ...

Author(s)
Fan JinJiang; Lefebvre, J.; Puttaswamy Manjunath
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Gene, 2006, 375, pp 63-74
Abstract

We conducted a comprehensive search for conserved elements in vertebrate genomes, using genome-wide multiple alignments of five vertebrate species (human, mouse, rat, chicken, and Fugu rubripes). Parallel searches were performed with multiple alignments of four insect species (three species of ...

Author(s)
Siepel, A.; Bejerano, G.; Pedersen, J. S.; Hinrichs, A. S.; Hou, M. M.; Rosenbloom, K.; Clawson, H.; Spieth, J.; Hillier, L. W.; Richards, S.; Weinstock, G. M.; Wilson, R. K.; Gibbs, R. A.; Kent, W. J.; Miller, W.; Haussler, D.
Publisher
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, USA
Citation
Genome Research, 2005, 15, 8, pp 1034-1050

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