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Abstract

Motivation: Evolutionary conservation of DNA sequences provides a tool for the identification of functional elements in genomes. We have created a database of evolutionary conserved regions (ECRs) in vertebrate genomes, entitled ECRbase, which is constructed from a collection of whole-genome...

Author(s)
Loots, G.; Ovcharenko, I.
Publisher
Oxford University Press, Oxford, UK
Citation
Bioinformatics, 2007, 23, 1, pp 122-124
Abstract

Background: A number of vertebrate highly conserved elements (HCEs) have been detected and their genomic interval distances have been reported to be more conserved than protein coding genes among mammalian genomes. A characteristic of the human - non-mammalian comparisons is a bimodal distribution...

Author(s)
Sun Hong; Skogerbø, G.; Zheng XiaoHui; Liu Wei; Li YiXue
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2009, 10, 133, pp (27 March 2009)
Abstract

Objective: The study aimed to clone interleukin-2 (IL-2) gene from Sichuan white goose. Method: Based on the IL-2 gene of duck accessed in GenBank, a pair of primers was designed for cloning IL-2 gene from total RNA of peripheral blood lymphocytes of Sichuan white goose stimulated by ConA via...

Author(s)
Ding Ke; Cheng AnChun; Wang MingShu; Zhu DeKang; Chen XiaoYue
Publisher
Hunan Academy of Agricultural Sciences, Changsha, China
Citation
Agricultural Science & Technology - Hunan, 2008, 9, 3, pp 80-84
Abstract

Tumour necrosis factor (TNF)-α is an important human cytokine that imparts dualism in malaria pathogenicity. At high dosages, TNF-α is believed to provoke pathogenicity in cerebral malaria; while at lower dosages TNF-α is protective against severe human malaria. To understand the human TNF-α gene...

Author(s)
Gauri Awasthi; Suchita Singh; Dash, A. P.; Aparup Das
Publisher
Contexto, Bahia, Brazil
Citation
Brazilian Journal of Infectious Diseases, 2008, 12, 5, pp 374-379
Abstract

We conducted a comprehensive search for conserved elements in vertebrate genomes, using genome-wide multiple alignments of five vertebrate species (human, mouse, rat, chicken, and Fugu rubripes). Parallel searches were performed with multiple alignments of four insect species (three species of ...

Author(s)
Siepel, A.; Bejerano, G.; Pedersen, J. S.; Hinrichs, A. S.; Hou, M. M.; Rosenbloom, K.; Clawson, H.; Spieth, J.; Hillier, L. W.; Richards, S.; Weinstock, G. M.; Wilson, R. K.; Gibbs, R. A.; Kent, W. J.; Miller, W.; Haussler, D.
Publisher
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, USA
Citation
Genome Research, 2005, 15, 8, pp 1034-1050
Abstract

A phylogenetic analysis of mammalian type-I interferon (IFN) genes was done. Species included cattle, sheep, goats, the musk ox, horses, pigs, dogs, fowls, mice and rats. The results showed (1) that the 3 main subfamilies of these genes in mammals (IFN-β, IFN-α and IFN-ω) diverged after the...

Author(s)
Hughes, A. L.
Citation
Journal of Molecular Evolution, 1995, 41, 5, pp 539-548

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