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Abstract

In mammals, cytosolic sensors retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) activate multiple signaling cascades initiating IFN-α/β expression. IFN regulatory factor 3 (IRF3) is required for the activation of IFN-β, which, in turn, primes the expression of most IFN-α genes by...

Author(s)
Sun Fan; Zhang YiBing; Liu TingKai; Shi Jun; Wang Bing; Gui JianFang
Publisher
American Association of Immunologists, Bethesda, USA
Citation
Journal of Immunology, 2011, 187, 5, pp 2531-2539
Abstract

Whole genome duplications (WGDs) are considered to have been a driving force in the generation of evolutionary diversity that is characteristic of higher eukaryotes. The ancestor of salmonids underwent two additional WGDs compared to mammals, one (3R) at the base of the teleost radiation and...

Author(s)
Lai, Y. Y. Y.; Lubieniecki, K. P.; Koop, B. F.; Davidson, W. S.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2012, 504, 2, pp 253-261
Abstract

Motivation: Evolutionary conservation of DNA sequences provides a tool for the identification of functional elements in genomes. We have created a database of evolutionary conserved regions (ECRs) in vertebrate genomes, entitled ECRbase, which is constructed from a collection of whole-genome...

Author(s)
Loots, G.; Ovcharenko, I.
Publisher
Oxford University Press, Oxford, UK
Citation
Bioinformatics, 2007, 23, 1, pp 122-124
Abstract

It has been suggested that the 4 transcription factor genes of the T-box gene family (Tbx2-Tbx5) played important roles in the course of vertebrate limb evolution. In the present work, the orthologues of tetrapod limb-expressed T-box genes from a teleost, zebrafish (Danio rerio), were...

Author(s)
Ruvinsky, I.; Oates, A. C.; Silver, L. M.; Ho, R. K.
Citation
Development, Genes and Evolution, 2000, 210, 2, pp 82-91

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