We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a segment of the rat genome and constitutes one of the largest contiguous sequences thus far for rodent...

The nucleotide sequences of the promoters of 9 rat MHC class I genes, from the 2 regions of the rat genome containing genes of this type, were analysed and compared with the sequences of mouse H2 loci. A purine-rich 44-bp segment, an element resembling the consensus sequence of heat shock proteins, ...

The roles of mutational and recombinational processes in the diversification of the exon encoding the antigen binding site in the murine MHC class II gene Ab were assessed by phylogenetic analysis of allelic nucleotide sequences. 46 alleles of Ab exon 2 from 12 Mus species or subspecies and 2 ...

Full-length cDNA sequences of 2 class I MHC molecules from the DA strain of Rattus norvegicus are presented. One coded for the classical class I restriction element RT1.A^a, which maps to the rat MHC. The other probably codes for a soluble non-classical class I molecule present in DA rat serum; a...

Comparison of the RT1 sequence with the sequences of the corresponding genes of the mouse (H-2A_β) and man (HLA-DQ_β) revealed that this gene has been highly conserved during evolution, and that some parts of the molecule are more conserved than others. Analysis of the nucleotide sequence encoding...