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Abstract

The interaction between blood-borne pathogens and fibrinolysis is one of the most important mechanisms that mediate invasion and the establishment of infectious agents in their hosts. However, overproduction of plasmin (final product of the route) has been related in other contexts to proliferation ...

Author(s)
González-Miguel, J.; Morchón, R.; Siles-Lucas, M.; Simón, F.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2015, 10, 4, pp e0124445
Abstract

Although there has been extensive veterinary focus on both the effectiveness of macrocyclic lactones for heartworm prevention in dogs and their adulticidal effects, little attention has been directed to their effects on heartworm microfilariae. With routine use of macrocyclic lactones, in some...

Author(s)
Bowman, D. D.; Mannella, C.
Publisher
Elsevier Inc, Orlando, USA
Citation
Topics in Companion Animal Medicine, 2011, 26, 4, pp 160-172
Abstract

Reports of loss-of-efficacy (LOE) events in dogs infected with Dirofilaria immitis despite adherence to accepted prophylaxis regimens with a macrocyclic lactone anthelmintic are attracting considerable attention. It is crucially important to distinguish among several possible causes for these LOE...

Author(s)
Geary, T. G.; Bourguinat, C.; Prichard, R. K.
Publisher
Elsevier Inc, Orlando, USA
Citation
Topics in Companion Animal Medicine, 2011, 26, 4, pp 186-192