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Reports of loss-of-efficacy (LOE) events in dogs infected with Dirofilaria immitis despite adherence to accepted prophylaxis regimens with a macrocyclic lactone anthelmintic are attracting considerable attention. It is crucially important to distinguish among several possible causes for these LOE...

Geary, T. G.; Bourguinat, C.; Prichard, R. K.
Elsevier Inc, Orlando, USA
Topics in Companion Animal Medicine, 2011, 26, 4, pp 186-192