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Abstract

Toll-like receptors (TLRs) play the key role in host defense of invasion of pathogens, not only in the innate immunity, but also in adaptive immunity. There are significant varieties and distinct features in fish TLRs, the TLR5 subfamily have two members (TLR5 M and TLR5S). However, the exact role...

Author(s)
Huo RuiXuan; Zhao XueYan; Han JingJing; Xu TianJun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Fish & Shellfish Immunology, 2018, 80, pp 109-114
Abstract

The suppressor of cytokine signaling 1 (SOCS1) is a crucial regulator in the immune systems of mammals, which functions classically as a negatively regulator in the IFN signaling pathways. However, data on functional characterization of SOCS1 in lower vertebrates is limited. In this study, we...

Author(s)
Zhao XueYan; Huo RuiXuan; Song WeiHua; Xu TianJun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2018, 78, pp 124-131
Abstract

Interferon regulatory factor (IRF) family is a transcription factor family which plays an important role in the regulation of natural immunity and immune cell differentiation. IRF7 is important to regulate the response of type I interferon (IFN) to viral infection. Thus, more researches of the...

Author(s)
Sun YueNa; Yang Qiong; Zhao XueYan; Liu XueZhu; Xu TianJun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Fish & Shellfish Immunology, 2018, 73, pp 50-56
Abstract

Interleukin (IL)-1β is a prototypical proinflammatory cytokine that belongs to the IL-1 family. This cytokine possesses two receptor types, namely, IL-1 receptor type I (IL-1RI) and IL-1 receptor type II (IL-1RII). IL-1RI, is an IL-1 receptor that plays a crucial role in immune responses and...

Author(s)
Yang Qiong; Chu Qing; Zhao XueYan; Xu TianJun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Fish & Shellfish Immunology, 2017, 63, pp 165-172
Abstract

Interferon regulatory factors (IRFs) are transcription factors which play important roles in regulating the expression of type I interferons (IFNs) and IFN-stimulated genes. IRF9 is one of the IRF family gene members which belongs to the IRF4 subfamily. Mammalian IRF9 has been known to be involved...

Author(s)
Yang Qiong; Cui JunXia; Song WeiHua; Zhao XueYan; Xu TianJun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Fish & Shellfish Immunology, 2017, 66, pp 524-530
Abstract

Being indispensable pattern recognition receptors in innate immune responses in host protection, Toll-like receptors (TLRs) play an important role in pathogen recognition. Fish TLRs exhibit high variety and distinct features, although little is known about their function on ligand recognition and...

Author(s)
Xu TianJun; Wang YanJin; Li JinRui; Shu Chang; Han JingJing; Chu Qing
Publisher
Elsevier Ltd, Oxford, UK
Citation
Fish & Shellfish Immunology, 2016, 56, pp 336-348
Abstract

The laboratory of genetics and physiology 2 (LGP2) is a member of retinoic acid-inducible gene I (RIG-I)-like receptors (RLR receptors), which may participate in the immune regulation process. The role of LGP2 on modulating signaling was ambiguous, some researchers suggested that the regulation...

Author(s)
Han JingJing; Wang YanJin; Chu Qing; Xu TianJun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Fish & Shellfish Immunology, 2016, 58, pp 193-202
Abstract

Interleukin-17 (IL-17) family is a cytokine family which is one of the major signaling molecules family involved in immunity. Six member of IL-17 family cytokines (IL-17A-F) were found in mammals. In fish, all IL-17 family genes except IL-17B and IL-17E have been isolated and identified. Besides,...

Author(s)
Yang Qiong; Sun Yuena; Su XiuRong; Li TaiWu; Xu TianJun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Fish & Shellfish Immunology, 2016, 49, pp 243-251
Abstract

IFN regulatory factor (IRF) 3 as an important member of IRF family, is required for the host antiviral response. In mammals, IRF3 is known to be a critical player in regulating the transcription of IFN and IFN-stimulated genes (ISGs). However, only a few studies investigated the characteristics of...

Author(s)
Shu Chang; Chu Qing; Bi DeKun; Wang YanJin; Xu TianJun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Fish & Shellfish Immunology, 2016, 54, pp 499-506
Abstract

NOD-like receptors (NLRs) are essential intracellular pattern-recognition receptors that respond to pathogens and regulate innate immunity. NLRs include three distinct subfamilies: NLR-A, NLR-B and NLR-C, thereinto, NLR-C as a large subfamily is unique to bony fish and little research about it has...

Author(s)
Li JinRui; Chu Qing; Xu TianJun
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2016, 61, pp 116-125

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