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Abstract

Avian influenza virus reassortants resembling the 1918 human pandemic virus can become transmissible among mammals by acquiring mutations in hemagglutinin (HA) and polymerase. Using the ferret model, we trace the evolutionary pathway by which an avian-like virus evolves the capacity for mammalian...

Author(s)
Moncla, L. H.; Zhong GongXun; Nelson, C. W.; Dinis, J. M.; Mutschler, J.; Hughes, A. L.; Watanabe, T.; Kawaoka, Y.; Friedrich, T. C.
Publisher
Cell Press, Cambridge, USA
Citation
Cell Host & Microbe, 2016, 19, 2, pp 169-180
Abstract

Nonhuman primates (NHPs) are a historically important source of zoonotic viruses and are a gold-standard model for research on many human pathogens. However, with the exception of simian immunodeficiency virus (SIV) (family Retroviridae), the blood-borne viruses harbored by these animals in the...

Author(s)
Bailey, A. L.; Lauck, M.; Ghai, R. R.; Nelson, C. W.; Heimbruch, K.; Hughes, A. L.; Goldberg, T. L.; Kuhn, J. H.; Jasinska, A. J.; Freimer, N. B.; Apetrei, C.; O'Connor, D. H.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Journal of Virology, 2016, 90, 15, pp 6724-6737
Abstract

In Diptera (Insecta), alternatively spliced male-specific and female-specific products of the doublesex (dsx) gene play a key role in regulating development of the adult genital structures from the genital disc. Analysis of the pattern of nucleotide substitution of different domains of the dsx gene ...

Author(s)
Hughes, A. L.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2011, 472, 1/2, pp 1-6
Abstract

Phylogenetic analysis of avian and other vertebrate fatty acid binding proteins (FABPs) supported the hypothesis that several gene duplications within this family occurred prior to the most recent common ancestor (MRCA) of tetrapods and bony fishes. The chicken genome encodes two liver-expressed...

Author(s)
Hughes, A. L.; Piontkivska, H.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Gene, 2011, 490, 1/2, pp 1-5
Abstract

GB virus B (GBV-B; family Flaviviridae, genus Hepacivirus) has been studied in New World primates as a model for human hepatitis C virus infection, but the distribution of GBV-B and its relatives in nature has remained obscure. Here, we report the discovery of a novel and highly divergent...

Author(s)
Lauck, M.; Sibley, S. D.; Lara, J.; Purdy, M. A.; Khudyakov, Y.; Hyeroba, D.; Tumukunde, A.; Weny, G.; Switzer, W. M.; Chapman, C. A.; Hughes, A. L.; Friedrich, T. C.; O'Connor, D. H.; Goldberg, T. L.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Journal of Virology, 2013, 87, 16, pp 8971-8981
Abstract

The poxviruses (family Poxviridae) are a family of double-stranded viruses including several species that infect humans and their domestic animals, most notably Variola virus (VARV), the causative agent of smallpox. The evolutionary biology of these viruses poses numerous questions, for which we...

Author(s)
Hughes, A. L.; Irausquin, S.; Friedman, R.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Infection, Genetics and Evolution, 2010, 10, 1, pp 50-59
Abstract

Both mean genomes size and the variance in genome size among species are smaller on average in birds (class Aves) than in the other tetrapod classes. In order to test whether loss of protein-coding genes has contributed to genome size reduction in birds, we compared the chicken genome and five...

Author(s)
Hughes, A. L.; Friedman, R.
Publisher
Oxford University Press, Oxford, UK
Citation
Molecular Biology and Evolution, 2008, 25, 12, pp 2681-2688
Abstract

Patterns of nucleotide substitution at orthologous loci were examined between three genomes of Ehrlichia ruminantium, the causative agent of heartwater disease of ruminants. The most recent common ancestor of two genomes (Erwe and Erwo) belonging to the Welgevonden strain was estimated to have...

Author(s)
Hughes, A. L.; French, J. O.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Gene, 2007, 387, pp 31-37
Abstract

Evidence of convergent evolution at the molecular sequence level in the putative peptide-binding regions of human and mouse MHC class Ib genes was obtained. Since these findings related to the functionally important peptide-binding region and since the primate and rodent molecules are known to bind ...

Author(s)
Yeager, M.; Sudhir Kumar; Hughes, A. L.
Citation
Molecular Biology and Evolution, 1997, 14, 10, pp 1035-1041
Abstract

The distribution of repeating sequences on 28 sequenced autosomes of the chicken with that on the 22 human autosomes were compared. It was shown that the number of repeat arrays varied from 319 on chromosome 16 to 283 761 on chromosome 1. The percentage of the chromosome occupied by repeats varied...

Author(s)
Hughes, A. L.; Piontkivska, H.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Evolutionary Biology, 2005, 5, 12, pp (04 February 2005)

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