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Abstract

Foot-and-mouth disease virus (FMDV) exhibits high mutation rates and replicates as complex and dynamic mixtures of related mutants termed viral quasispecies. Here we review the basics of quasispecies theory, how FMDV helped to establish a link between theory and experimental observations, and some...

Author(s)
Domingo, E.; Higuera, I. de la; Moreno, E.; Ávila, A. I. de; Agudo, R.; Arias, A.; Perales, C.
Publisher
Caister Academic Press, Norfolk, UK
Citation
Foot-and-mouth disease virus: current research and emerging trends, 2017, pp 147-170
Abstract

Foot-and-mouth disease virus (FMDV) exhibits high mutation rates and replicates as complex and dynamic mixtures of related mutants termed viral quasispecies. Here we review the basics of quasispecies theory, how FMDV helped to establish a link between theory and experimental observations, and some...

Author(s)
Domingo, E.; Higuera, I. de la; Moreno, E.; Ávila, A. I. de; Agudo, R.; Arias, A.; Perales, C.
Publisher
Caister Academic Press, Poole, UK
Citation
Foot-and-mouth disease virus: current research and emerging trends, 2017, pp 147-170
Abstract

Fifteen years after the devastating 2001 European foot-and-mouth disease (FMD) outbreak, the virus causing that shocking episode continues to pose a major threat to animal health worldwide. The development of more effective, sustainable and socially acceptable disease control measures remains a key ...

Author(s)
Sobrino, F.; Domingo, E.
Publisher
Caister Academic Press, Poole, UK
Citation
Foot-and-mouth disease virus: current research and emerging trends, 2017, pp xii + 432 pp.
Abstract

Although foot-and-mouth disease vaccines were in use at least since the 40s the policy of applying vaccination as a preventive tool and to respond to incursions in free countries, known as 'vaccination to live', only recently gained acceptance. This is reflected in changes in the World Organisation ...

Author(s)
Smitsaart, E. N.; Bergmann, I. E.
Publisher
Caister Academic Press, Poole, UK
Citation
Foot-and-mouth disease virus: current research and emerging trends, 2017, pp 287-316
Abstract

Based on the most recent basic and clinical research findings, this book encapsulates current knowledge of the molecular biology, evolution and pathogenesis of the picornaviruses. In addition, it examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent...

Author(s)
Ehrenfeld, E.; Domingo, E.; Roos, R. P.
Publisher
ASM Press, Washington, USA
Citation
The picornaviruses, 2010, pp xiv + 493 pp.
Abstract

Foot-and-mouth disease virus (FMDV), as other RNA viruses characterized to date, exists and replicates as complex and dynamic mixtures of related mutants termed viral quasispecies. In this chapter we review the conceptual origins of quasispecies, and the molecular basis and biological implications...

Author(s)
Domingo, E.; Ruiz-Jarabo, C. M.; Arias, A.; García-Arriaza, J.; Escarmís, C.
Publisher
Horizon Bioscience, Wymondham, UK
Citation
Foot and mouth disease: current perspectives, 2004, pp 261-304
Abstract

Author(s)
Domingo, E.
Publisher
Foundation Marcel Merieux, Lyon, France
Citation
Immunobiology of viral infections. Proceedings 3rd Congress of the European Society for Veterinary Virology Interlaken, Switzerland, 4-7 September, 1994., 1995, pp 9-15
Abstract

If we could rewind the tape of evolution and play it again, would it turn out to be similar to or different from what we know? Obviously, this key question can only be addressed by fragmentary experimental approaches. Twenty-two years ago, we described the establishment of BHK-21 cells persistently ...

Author(s)
Herrera, M.; Grande-Pérez, A.; Perales, C.; Domingo, E.
Publisher
Society for General Microbiology, Reading, UK
Citation
Journal of General Virology, 2008, 89, 1, pp 232-244
Abstract

Background: The evolution of viral quasispecies can influence viral pathogenesis and the response to antiviral treatments. Mutant clouds in infected organisms represent the first stage in the genetic and antigenic diversification of RNA viruses, such as foot and mouth disease virus (FMDV), an...

Author(s)
Martín, V.; Perales, C.; Abia, D.; Ortíz, A. R.; Domingo, E.; Briones, C.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genomics, 2006, 7, 117, pp (18 May 2006)
Abstract

Author(s)
Domingo, E.; Escarmís, C.; Baranowski, E.; Ruiz-Jarabo, C. M.; Carrillo, E.; Núñez, J. I.; Sobrino, F.
Publisher
Elsevier Science Ltd, Oxford, UK
Citation
Virus Research, 2003, 91, 1, pp 47-63

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