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Abstract

The X or Z chromosome has several characteristics that distinguish it from the autosomes, namely hemizygosity in the heterogametic sex, and a potentially different effective population size, both of which may influence the rate and nature of evolution. In particular, there may be an accelerated...

Author(s)
Mank, J. E.; Vicoso, B.; Berlin, S.; Charlesworth, B.
Publisher
Blackwell Publishing Ltd, Oxford, UK
Citation
Evolution : International Journal of Organic Evolution, 2010, 64, 3, pp 663-674
Abstract

Associations between selected alleles and the genetic backgrounds on which they are found can reduce the efficacy of selection. We consider the extent to which such interference, known as the Hill-Robertson effect, acting between weakly selected alleles, can restrict molecular adaptation and affect ...

Author(s)
McVean, G. A. T.; Charlesworth, B.
Citation
Genetics, 2000, 155, 2, pp 929-944
Abstract

A diffusion approximation was derived that described the effects of the presence of a single locus subject to mutation and strongly deleterious selection on variation and evolution at a partially linked, weakly selected locus. The results were validated by computer simulations using the Ito...

Author(s)
Stephan, W.; Charlesworth, B.; McVean, G.
Citation
Genetical Research, 1999, 73, 2, pp 133-146
Abstract

Recent analyses have suggested that the local frequency of genetic recombination is related to the GC base content of the local DNA sequence. This may reflect the greater efficacy of natural selection in regions of the genome where recombination is more frequent. It is recommended that genome...

Author(s)
Charlesworth, B.
Citation
Current Biology, 1994, 4, 2, pp 182-184
Abstract

Although wild-type alleles are generally dominant over mutant alleles, recently established alleles for pesticide resistance are rarely recessive in combination with their progenitors. This seems to be caused by a combination of a 'selective sieve' favouring non-recessive mutations, and the...

Author(s)
Charlesworth, B.
Citation
Current Biology, 1998, 8, 14, pp R502-R504
Abstract

A review. Rates of spontaneous mutation per genome as measured in the laboratory are remarkably similar within broad groups of organisms but differ strikingly among groups. Mutation rates in RNA viruses, whose genomes contain ∼ 104 bases, are roughly 1 per genome per replication for lytic viruses...

Author(s)
Drake, J. W.; Charlesworth, B.; Charlesworth, D.; Crow, J. F.
Citation
Genetics, 1998, 148, 4, pp 1667-1686
Abstract

Theoretical arguments are presented which suggest that each advance of Muller's ratchet in a haploid asexual population causes the fixation of a deleterious mutation at a single locus. A similar process operates in a diploid, fully asexual population under a wide range of parameter values, with...

Author(s)
Charlesworth, B.; Charlesworth, D.
Citation
Genetical Research, 1997, 70, 1, pp 63-73
Abstract

This review of work in animals and plants considers the evolutionary origin of sex chromosomes, the evolution of a degenerate Y-chromosome and of dosage compensation with respect to sex-linked genes, and the accumulation of repeated DNA sequences on the Y-chromosome.

Author(s)
Charlesworth, B.
Citation
Science (Washington), 1991, 251, 4997, pp 1030-1033
Abstract

An analysis was made of the effects of deleterious alleles maintained by mutation (background selection) on rates of evolution and levels of genetic diversity at weakly selected, completely linked loci. General formulae were derived for the expected rates of gene substitution and genetic diversity, ...

Author(s)
Charlesworth, B.
Citation
Genetical Research, 1994, 63, 3, pp 213-227
Abstract

This book examines evolution in age-structured populations of animals and plants under the following headings: models of age-structured populations; the genetics of populations without selection; selection: construction of a model and the properties of equilibrium populations; selection: dynamic...

Author(s)
Charlesworth, B.
Publisher
Cambridge University Press, Cambridge, UK
Citation
Evolution in age-structured populations., 1994, Ed. 2, pp xiii + 306 pp.

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