The present study aimed to report the case of a canine patient, mixed breed, weighing 40 kg, 13 years old and spayed, after presenting pyometritis at 9 years of age. Malignant tumors are predominant in dogs that are unspayed or spayed later in life, with the common presence of multiple nodes in any ...

Neoplasia in porcupines is rarely reported in the literature, and the prevalence is unknown. A retrospective review of records from a private zoo diagnostic pathology service found four cases of mammary adenocarcinoma in Indian crested porcupines (Hystrix indica) from four separate zoological...

Background: In recent years increased frequency of mammary gland neoplasms have been reported in captive wild felids. Basing on published data, in tigers mammary gland carcinoma always seems to be highly invasive and metastatic. The present report describes a case of Mammary carcinoma with...

The role of HER2 in canine mammary tumors is not completely elucidated, and the contradictory results published so far may be, in part, explained by the genetic variability recognized in the canine HER2 gene. Single nucleotide polymorphism (SNPs) in HER2 were recently associated with less...

Novel, well-tolerated drugs are needed for the management of canine mammary cancer. Many of these cancers are promoted in their growth by estrogen. Alpha-fetoprotein (AFP) is a ubiquitous mammalian protein that has anti-estrogenic properties. AFPep (the anti-estrogenic site of AFP) has been...

This summary on mammary tumors in dogs aims to provide an overall and brief description of the disease, appropriate diagnostics and suggestions for treatment principles based on published data. At the same time, there is a lot of ongoing research in new diagnosis and treatment which will not be...

Mammary gland tumors are the most common neoplasms in female dogs, of which 50% are malignant. Esculetin, a coumarin derivative, reportedly induces death in different types of cancer cells. In this study, we explore the anticancer effects of esculetin against CMT-U27 and CF41.mg canine mammary...

The study of the structure and function of the animals' mammary glands is of key importance, as it reveals pathological processes at their onset, thus contributing to their immediate treatment. The most frequently studied mammary diseases are mastitis in cows and ewes and mammary tumours in dogs...

Surgical excision of solid tumors is required for local control of neoplasms. However, surgical trauma can stimulate the release of proangiogenic growth factors, suppressing cell-mediated immunity and favoring the development of micrometastases and progression of residual disease. The present study ...

Foxp3+ cell counts were evaluated by immunohistochemistry in 59 canine mammary tumors, 20 adenomas, and 39 carcinomas in three different compartments: intratumoral, within the adjacent stroma, and in the distant stroma. Foxp3+ lymphocyte counts were compared with histotype, grading, presence of...