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Abstract

Receptors for the Fc region of IgG (FcγRs) play a key role in protecting the immune system and host from infection. In this study, we described the cloning, sequencing and characterization of porcine FcγRI, and reported six different FcγRI isoforms, four of which have never been reported before....

Author(s)
Shi PeiDian; Su YanXin; Li Yi; Zhang LiLin; Lu Dong; Li RuiQiao; Zhang Lei; Huang JinHai
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2019, 90, pp 186-198
Abstract

RIG-I like receptor (RLR) signaling functions importantly in host innate immune response against RNA virus, which is tightly regulated by a number of mechanisms to prevent aberrant interferon production. The suppressor of IKKε (SIKE) has been identified as a suppressor of IKKε and TBK1, which are...

Author(s)
Li Jun; Yan ChuanZhe; Liu Ji; Yan Jun; Feng Hao
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2019, 90, pp 157-164
Abstract

In vertebrates, the T cell receptor (TCR) plays a crucial role in immune system. To date, the roles of fish TCRs in response to pathogen infection are still poorly understood. In the present study, we firstly cloned and identified the TCRα and TCRβ from dojo loach (Misgurnus anguillicaudatus) by...

Author(s)
Yu Wei; Luo YanZhi; Yu YongYao; Dong Shuai; Yin YaXing; Huang ZhenYu; Xu Zhen
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2019, 90, pp 90-99
Abstract

Mx proteins are antiviral GTPases, which are induced by type I IFN and virus infection. Analysis of the Atlantic salmon genome revealed the presence of 9 Mx genes localized to three chromosomes. A cluster of three Mx genes (SsaMx1-SsaMx3), which includes previously cloned Mx genes, is present on...

Author(s)
Robertsen, B.; Greiner-Tollersrud, L.; Jørgensen, L. G.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2019, 90, pp 80-89
Abstract

Human and mouse CD83 have been well characterized, however, the other mammalian CD83 genes have not been cloned and characterized. In this study, the porcine CD83 (pCD83) was cloned, expressed and characterized, and showed that the pCD83 gene has 81% and 74% homologies with humans and mice,...

Author(s)
Huo ShanShan; Zhang JianLou; Wu FengYang; Zuo YuZhu; Cui Dan; Li XiuJin; Zhong ZhenYu; Zhong Fei
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2019, 90, pp 60-69
Abstract

The regulation of interferon-α signaling pathways is essential to protect the host from infection with a broad range of viruses. However, information regarding antiviral response and the specific molecular mechanism of Columba livia interferon-α (CoIFN-α) has not been reported to date. In this...

Author(s)
Li SiWen; Wang Yu; Zhao HongJing; Shao YiZhi; Liu JuanJuan; Xing MingWei
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2019, 90, pp 29-40
Abstract

Chemokines comprise a group of small molecular weight (6-14 kDa) cytokines; chemokine receptors are a superfamily of seven transmembrane domain G-coupled receptors. Both chemokines and their receptors have important roles in immune surveillance, inflammation, and development. Recently, 9 CXC...

Author(s)
Wang Qing; Wang ShaoWen; Zhang Yong; Yu YePin; Zhao HuiHong; Yang HuiRong; Zheng LeYun; Yang Min; Qin QiWei
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2019, 90, pp 10-20
Abstract

Caspase, an aspartate specific proteinase mediating apoptosis, plays a key role in immune response. In our previous study, the expression of a caspase gene was up-regulated in a transcriptome library from the haematopoietic tissue (Hpt) cells of red claw crayfish Cherax quadricarinatus post white...

Author(s)
Li YanYao; Xie XiaoLu; Ma XingYuan; Liu HaiPeng
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2019, 91, pp 101-107
Abstract

Type I IFNs are a family of cytokines with antiviral, anti-proliferative and immune-modulatory functions. In this study, four type I IFNs (termed AjIFN1-4) have been cloned from the Japanese eel, Anguilla japonica. The open reading frames of AjIFN1-4 are 552, 534, 546 and 561 bp in length, encoding ...

Author(s)
Huang, B.; Wang, Z. X.; Liang, Y.; Zhai, S. W.; Huang, W. S.; Nie, P.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2019, 91, pp 62-71
Abstract

Lipopolysaccharides (LPS) can induce the apoptosis of coelomocytes in Apostichopus japonicus (A. japonicus), and β-integrin serves as an apoptotic inhibitor during this process. However, the underlying mechanism in invertebrates is largely unknown. Integrin/focal adhesion kinase (FAK) signaling...

Author(s)
Wang ZhenHui; Li ChengHua; Xing RongLian; Shao YiNa; Zhao XueLin; Zhang WeiWei; Guo Ming
Publisher
Elsevier Ltd, Oxford, UK
Citation
Developmental and Comparative Immunology, 2019, 91, pp 26-36

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