Despite numerous efforts, developing recombinant vaccines for the control of M. bovis infections has not been successful. Many factors are contributing to the lack of success including the identification of protective antigens, use of effective adjuvants, and relatively limited information on the...
Author(s)
Prysliak, T.; Menghwar, H.; Perez-Casal, J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Vaccine, 2023, 41, 10, pp 1743-1752
Tuberculosis caused by Mycobacterium bovis is a serious problem for animal and human health worldwide. A promising concept for the design of anti-tuberculosis drugs is the conjugation of an immunogenic fraction isolated from bacterial vaccines with a stimulating component. Taking this principle as...
Author(s)
Koshkin, I. N.; Vlasenko, V. S.; Pleshakova, V. I.; Alkhimova, L. E.; Elyshev, A. V.; Kulakov, I. V.
Publisher
MDPI AG, Basel, Switzerland
Citation
Vaccines, 2022, 10, 12,
Although France is officially declared free of bovine tuberculosis (TB), Mycobacterium bovis infection is still observed in several regions in cattle and wildlife, including badgers (Meles meles). In this context, vaccinating badgers should be considered as a promising strategy for the reduction in ...
Author(s)
Payne, A.; Ruette, S.; Jacquier, M.; Richomme, C.; Lesellier, S.; Middleton, S.; Duhayer, J.; Rossi, S.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2022, 8, March,
Bovine tuberculosis (bTB) is one of the top three, high-priority, livestock diseases in Ethiopia and hence, the need for evaluation of potential control strategies is critical. Here, we applied the test-and-segregate followed by cull strategy for the control of bTB in the intensive Alage dairy farm ...
Author(s)
Matios Lakew; Srinivasan, S.; Beruhtesfa Mesele; Abebe Olani; Tafesse Koran; Biniam Tadesse; Getnet Abie Mekonnen; Gizat Almaw; Temertu Sahlu; Bekele Seyoum; Kebede Beyecha; Balako Gumi; Gobena Ameni; Hagos Ashenafi; Bakker, D.; Kapur, V.; Gebre, S.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2022, 8, March,
Publisher
Veterinary Ireland, Dublin, Irish Republic
Citation
Veterinary Ireland Journal, 2022, 12, 2, pp 83-84
It has been established that kallikrein12 (KLK12) expression is closely related to bovine tuberculosis (bTB) development. Herein, we sought to clarify the regulatory mechanism of KLK12 and its application in tuberculosis diagnosis. KLK12 knockdown macrophages were produced by siRNA transfection....
Author(s)
Wang YuanZhi; Qu MengJin; Liu YiDuo; Wang HaoRan; Dong YuHui; Zhou XiangMei
Publisher
MDPI AG, Basel, Switzerland
Citation
International Journal of Molecular Sciences, 2022, 23, 20,
Foot-and-mouth disease virus (FMDV) is small RNA virus from Picornaviridae family; genus Aphthovirus. FMDV causes maximum levels of infectivity in cattle and harmful socioeconomic effects. The present report attempted to design vaccine candidate from the polyprotein of FMDV to stimulate protective...
Author(s)
Ahmed, R. M. S.; Almofti, Y. A.; Abd-Elrahman, K. A.
Publisher
Dr. M N Khan, Bhopal, India
Citation
Journal of Pure and Applied Microbiology, 2022, 16, 3, pp 2083-2098
The aim of this study was to investigate the method of in vitro isolation and culture of bovine alveolar epithelial cells (BAECs) and the regulatory mechanism of Wnt5a on the autophagy of BAECs infected with Mycobacterium tuberculosis bacille Calmette-Guérin (BCG). BAECs were isolated by enzyme...
Author(s)
Chen Qi; Du ChangZheng; Zheng XueDi; Ma BoLi; Xu JinRui; Yang Yi
Publisher
Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China
Citation
Acta Veterinaria et Zootechnica Sinica, 2022, 53, 11, pp 4071-4080
Bovine tuberculosis (bTB) is a global disease of livestock that has damaging economic, animal health and public health consequences. Conventional bTB disease control strategies, based around the testing and slaughter of cattle infected with bTB, are typically used to help limit or reduce the...
Author(s)
Williams, G. A.; Scott-Baird, E.; Núñez, A.; Salguero, F. J.; Wood, E.; Houghton, S.; Vordermeier, H. M.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Heliyon, 2022, 8, 12,
The Bacillus Calmette-Guérin (BCG) vaccination provides partial protection against, and reduces severity of pathological lesions associated with bovine tuberculosis (bTB) in cattle. Accumulating evidence also suggests that revaccination with BCG may be needed to enhance the duration of immune...
Author(s)
Saraswathi Subramanian; Sreenidhi Srinivasan; Selvaraju, K. R.; Vinoli, P. M.; Suganya Selladurai; Boominathan Ramasamy; Karthik Kumaragurubaran; Douwe Bakker; Martin Vordermeier; Vivek Kapur; Gopal, D. R.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2022, 8, April,