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Abstract

European badgers (Meles meles) are a wildlife reservoir for Mycobacterium bovis (M. bovis) in parts of England, Wales and Ireland, constituting a potential source of tuberculosis (TB) infection for cattle. Vaccination of badgers against TB is one of the tools available for helping reduce the...

Author(s)
Perrett, S.; Lesellier, S.; Rogers, F.; Williams, G. A.; Gowtage, S.; Palmer, S.; Dalley, D.; Davé, D.; Weyer, U.; Wood, E.; Salguero, F. J.; Nunez, A.; Reed, N.; Chambers, M. A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Vaccine, 2018, 36, 15, pp 1990-1995
Abstract

The European badger (Meles meles) is a reservoir host of Mycobacterium bovis and responsible for a proportion of the tuberculosis (TB) cases seen in cattle in the United Kingdom and Republic of Ireland. An injectable preparation of the bacillus Calmette-Guérin (BCG) vaccine is licensed for use in ...

Author(s)
Chambers, M. A.; Aldwell, F.; Williams, G. A.; Palmer, S.; Gowtage, S.; Ashford, R.; Dalley, D. J.; Davé, D.; Weyer, U.; Salguero, F. J.; Nunez, A.; Nadian, A. K.; Crawshaw, T.; Corner, L. A. L.; Lesellier, S.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Cellular and Infection Microbiology, 2017, 7, January, pp 6
Abstract

The oral vaccination of wild badgers (Meles meles) with live Bacillus Calmette-Guérin (BCG) is one of the tools being considered for the control of bovine tuberculosis (caused by Mycobacterium bovis) in the UK. The design of a product for oral vaccination requires that numerous, and often...

Author(s)
Gowtage, S.; Williams, G. A.; Henderson, R.; Aylett, P.; MacMorran, D.; Palmer, S.; Robertson, A.; Lesellier, S.; Carter, S. P.; Chambers, M. A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Vaccine, 2017, 35, 6, pp 987-992
Abstract

Environmental air sampling was evaluated as a method to detect the presence of M. bovis in the vicinity of infected badgers and their setts. Airborne particles were collected on gelatine filters using a commercially available air sampling instrument and tested for the presence of M. bovis using...

Author(s)
Jones, R. M.; Ashford, R.; Cork, J.; Palmer, S.; Wood, E.; Spyvee, P.; Parks, S.; Bennett, A.; Brewer, J.; Delahay, R.; Chambers, M.; Sawyer, J.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Letters in Applied Microbiology, 2013, 56, 5, pp 361-365
Abstract

Control of bovine tuberculosis (TB) in cattle has proven particularly challenging where reservoirs of infection exist in wildlife populations. In Britain and Ireland, control is hampered by a reservoir of infection in Eurasian badgers (Meles meles). Badger culling has positive and negative effects...

Author(s)
Chambers, M. A.; Rogers, F.; Delahay, R. J.; Lesellier, S.; Ashford, R.; Dalley, D.; Gowtage, S.; Davé, D.; Palmer, S.; Brewer, J.; Crawshaw, T.; Clifton-Hadley, R.; Carter, S.; Cheeseman, C.; Hanks, C.; Murray, A.; Palphramand, K.; Pietravalle, S.; Smith, G. C.; Tomlinson, A.; Walker, N. J.; Wilson, G. J.; Corner, L. A. L.; Rushton, S. P.; Shirley, M. D. F.; Gettinby, G. (et al)
Publisher
Royal Society, London, UK
Citation
Proceedings of the Royal Society B. Biological Sciences, 2011, 278, 1713, pp 1913-1920
Abstract

In this paper we report the development of a sensitive and specific assay for the detection of tuberculosis (TB) in European badgers (Meles meles), based on the stimulation of lymphocytes in whole-blood culture and the subsequent detection of gamma-interferon (IFNγ) by sandwich ELISA. The...

Author(s)
Dalley, D.; Davé, D.; Lesellier, S.; Palmer, S.; Crawshaw, T.; Hewinson, R. G.; Chambers, M.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Tuberculosis, 2008, 88, 3, pp 235-243
Abstract

Mycobacterium bovis infection is widespread in Eurasian badger (Meles meles) populations in Great Britain and the Republic of Ireland where they act as a wildlife reservoir of infection for cattle. Removal of infected badgers can significantly reduce the incidence of bovine tuberculosis (TB) in...

Author(s)
Lesellier, S.; Palmer, S.; Gowtage-Sequiera, S.; Ashford, R.; Dalley, D.; Davé, D.; Weyer, U.; Salguero, F. J.; Nunez, A.; Crawshaw, T.; Corner, L. A.; Hewinson, R. G.; Chambers, M. A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Vaccine, 2011, 29, 21, pp 3782-3790
Abstract

Bovine tuberculosis (bTB) is an important disease of cattle and an emerging infectious disease of humans. Cow- and badger-based control strategies have failed to eradicate bTB from the British cattle herd, and the incidence is rising by about 18% per year. The annual cost to taxpayers in Britain is ...

Author(s)
Mathews, F.; Macdonald, D. W.; Taylor, G. M.; Gelling, M.; Norman, R. A.; Honess, P. E.; Foster, R.; Gower, C. M.; Varley, S.; Harris, A.; Palmer, S.; Hewinson, G.; Webster, J. P.
Publisher
Royal Society, London, UK
Citation
Proceedings of the Royal Society B. Biological Sciences, 2006, 273, 1584, pp 357-365
Abstract

European badgers (Meles meles) are a wildlife reservoir for Mycobacterium bovis (M. bovis) in Great Britain (GB) and the Republic of Ireland and therefore constitute a potential source of infection for cattle. Reduction of badger densities in the Republic of Ireland has resulted in an associated...

Author(s)
Lesellier, S.; Palmer, S.; Dalley, D. J.; Davé, D.; Johnson, L.; Hewinson, R. G.; Chambers, M. A.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2006, 112, 1/2, pp 24-37
Abstract

A real-time PCR assay for the measurement of gamma interferon (IFN-γ) mRNA in European badger (Meles meles) blood cultures was developed. The levels of IFN-γ mRNA in blood cultures stimulated with either bovine or avian tuberculin or specific mycobacterial antigens were compared with those in a...

Author(s)
Sawyer, J.; Mealing, D.; Dalley, D.; Davé, D.; Lesellier, S.; Palmer, S.; Bowen-Davies, J.; Crawshaw, T. R.; Chambers, M. A.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Journal of Clinical Microbiology, 2007, 45, 8, pp 2398-2403

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