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Abstract

Mycobacterium bovis is the main cause of bovine tuberculosis and its eradication is proving difficult in many countries because of wildlife reservoirs, including European badgers (Meles meles) in the UK Ireland. Following the development of badger specific immunological reagents, many studies have...

Author(s)
Lesellier, S.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Comparative Immunology, Microbiology & Infectious Diseases, 2018, 61, pp 9-15
Abstract

Background: Bovine tuberculosis (bTB) caused by Mycobacterium bovis is the most serious endemic disease affecting livestock in the UK. The European badger (Meles meles) is the most important wildlife reservoir of bTB transmission to cattle, making eradication particularly difficult. In this...

Author(s)
Stedman, A.; Motes, C. M. de; Lesellier, S.; Dalley, D.; Chambers, M.; Gutierrez-Merino, J.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Microbiology, 2018, 18, 74, pp (13 July 2018)
Abstract

European badgers (Meles meles) are a wildlife reservoir for Mycobacterium bovis (M. bovis) in parts of England, Wales and Ireland, constituting a potential source of tuberculosis (TB) infection for cattle. Vaccination of badgers against TB is one of the tools available for helping reduce the...

Author(s)
Perrett, S.; Lesellier, S.; Rogers, F.; Williams, G. A.; Gowtage, S.; Palmer, S.; Dalley, D.; Davé, D.; Weyer, U.; Wood, E.; Salguero, F. J.; Nunez, A.; Reed, N.; Chambers, M. A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Vaccine, 2018, 36, 15, pp 1990-1995
Abstract

In developing an oral bait BCG vaccine against tuberculosis in badgers we wanted to understand the conditions of the gastrointestinal tract and their impact on vaccine viability. Conditions mimicking stomach and small-intestine caused substantial reduction in BCG viability. We performed in vivo...

Author(s)
Williams, G. A.; Koenen, M. E.; Havenaar, R.; Wheeler, P.; Gowtage, S.; Lesellier, S.; Chambers, M. A.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 4, pp e0214859
Abstract

European badgers (Meles meles) are considered to be an important reservoir of infection for Mycobacterium bovis and are implicated in the transmission of tuberculosis to cattle in Ireland and Great Britain. Accurate tests are required for tuberculosis surveillance in badger populations and to...

Author(s)
Lesellier, S.; Corner, L.; Costello, E.; Sleeman, P.; Lyashchenko, K.; Greenwald, R.; Esfandiari, J.; Mahavir Singh; Hewinson, R. G.; Chambers, M.; Gormley, E.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2008, 122, 1/2, pp 35-45
Abstract

European badgers (Meles meles) have been identified as wildlife reservoirs for Mycobacterium bovis in the UK and Ireland, and may also have a role in the epidemiology of animal tuberculosis in other European regions. Thus, detection of M. bovis-infected badgers may be required for the purposes of...

Author(s)
Infantes-Lorenzo, J. A.; Dave, D.; Moreno, I.; Anderson, P.; Lesellier, S.; Gormley, E.; Dominguez, L.; Balseiro, A.; Gortázar, C.; Dominguez, M.; Salguero, F. J.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Medicine and Science, 2019, 5, 1, pp 61-69
Abstract

The European badger (Meles meles) is a reservoir host of Mycobacterium bovis and responsible for a proportion of the tuberculosis (TB) cases seen in cattle in the United Kingdom and Republic of Ireland. An injectable preparation of the bacillus Calmette-Guérin (BCG) vaccine is licensed for use in ...

Author(s)
Chambers, M. A.; Aldwell, F.; Williams, G. A.; Palmer, S.; Gowtage, S.; Ashford, R.; Dalley, D. J.; Davé, D.; Weyer, U.; Salguero, F. J.; Nunez, A.; Nadian, A. K.; Crawshaw, T.; Corner, L. A. L.; Lesellier, S.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Cellular and Infection Microbiology, 2017, 7, January, pp 6
Abstract

European badgers (Meles meles) are a reservoir host of Mycobacterium bovis and are implicated in the transmission of tuberculosis to cattle in Ireland and Great Britain. The development of a vaccine for use in badgers is considered a key element of any campaign to eradicate the disease in livestock ...

Author(s)
Lesellier, S.; Corner, L.; Costello, E.; Lyashchenko, K.; Greenwald, R.; Esfandiari, J.; Mahavir Singh; Hewinson, R. G.; Chambers, M.; Gormley, E.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Vaccine, 2009, 27, 3, pp 402-409
Abstract

The oral vaccination of wild badgers (Meles meles) with live Bacillus Calmette-Guérin (BCG) is one of the tools being considered for the control of bovine tuberculosis (caused by Mycobacterium bovis) in the UK. The design of a product for oral vaccination requires that numerous, and often...

Author(s)
Gowtage, S.; Williams, G. A.; Henderson, R.; Aylett, P.; MacMorran, D.; Palmer, S.; Robertson, A.; Lesellier, S.; Carter, S. P.; Chambers, M. A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Vaccine, 2017, 35, 6, pp 987-992
Abstract

Vaccination of badgers by the subcutaneous, mucosal and oral routes with the Pasteur strain of Mycobacterium bovis bacille Calmette-Guérin (BCG) has resulted in significant protection against experimental infection with virulent M. bovis. However, as the BCG Danish strain is the only commercially...

Author(s)
Murphy, D.; Costello, E.; Aldwell, F. E.; Lesellier, S.; Chambers, M. A.; Fitzsimons, T.; Corner, L. A. L.; Gormley, E.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2014, 200, 3, pp 362-367

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