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Abstract

In developing an oral bait BCG vaccine against tuberculosis in badgers we wanted to understand the conditions of the gastrointestinal tract and their impact on vaccine viability. Conditions mimicking stomach and small-intestine caused substantial reduction in BCG viability. We performed in vivo...

Author(s)
Williams, G. A.; Koenen, M. E.; Havenaar, R.; Wheeler, P.; Gowtage, S.; Lesellier, S.; Chambers, M. A.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 4, pp e0214859
Abstract

European badgers (Meles meles) have been identified as wildlife reservoirs for Mycobacterium bovis in the UK and Ireland, and may also have a role in the epidemiology of animal tuberculosis in other European regions. Thus, detection of M. bovis-infected badgers may be required for the purposes of...

Author(s)
Infantes-Lorenzo, J. A.; Dave, D.; Moreno, I.; Anderson, P.; Lesellier, S.; Gormley, E.; Dominguez, L.; Balseiro, A.; Gortázar, C.; Dominguez, M.; Salguero, F. J.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Medicine and Science, 2019, 5, 1, pp 61-69
Abstract

Culling wildlife to control disease can lead to both decreases and increases in disease levels, with apparently conflicting responses observed, even for the same wildlife-disease system. There is therefore a pressing need to understand how culling design and implementation influence culling's...

Author(s)
Prentice, J. C.; Fox, N. J.; Hutchings, M. R.; White, P. C. L.; Davidson, R. S.; Marion, G.
Publisher
The Royal Society, London, UK
Citation
Journal of the Royal Society Interface, 2019, 16, 152, pp 20180901
Abstract

In Great Britain (GB) overall, approximately nine new incidents of bovine TB (bTB) were detected in 2017 for every 100 herds that underwent a full year of surveillance, a slight increase from the 2016 figure of 8.4. There was substantial variation across GB at country, surveillance risk area and...

Author(s)
Perrin, L. D.; Harris, K. A.; Lawes, J. R.; Frost, S.; Brouwer, A.; Dale, J.; Palkopoulou, E.; Upton, P. A.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2019, 184, 12, pp 371-378
Abstract

This article highlights the need to focused on breaking pathways of transmission (for bovine tuberculosis), whether they be cow to-cow transmission within a herd or between herds, or wildlife-to-cow, or vice versa, transmission. This strategy was recommended since there are limitations with regards ...

Author(s)
Cutler, K. L.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2019, 184, 8, pp 258-259
Abstract

Author(s)
Jones, T. O.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2019, 184, 2, pp 67-68
Abstract

Author(s)
Drouin, R.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2019, 184, 1, pp 31
News Article

Gut commensal bacteria could play a role in influencing the outcome of oral BCG vaccination

Date
9 October 2018
News Article

Field trials recommended by the EU would have to be extremely large to show a benefit of vaccination, researchers say

Date
12 June 2018
Abstract

Background: Bovine tuberculosis (bTB) caused by Mycobacterium bovis is the most serious endemic disease affecting livestock in the UK. The European badger (Meles meles) is the most important wildlife reservoir of bTB transmission to cattle, making eradication particularly difficult. In this...

Author(s)
Stedman, A.; Motes, C. M. de; Lesellier, S.; Dalley, D.; Chambers, M.; Gutierrez-Merino, J.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Microbiology, 2018, 18, 74, pp (13 July 2018)

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