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Abstract

Senecavirus A (SVA) is a newly emerging causative agent of vesicular diseases in swine characterized with wide genetic diversity and rapid evolution. The lack of immunologically active cell culture model impedes the study of SVA-specific innate immunity. Here, an immortalized porcine alveolar...

Author(s)
Dang Wen; Li Tao; Xu Fan; Wang YanNan; Yang Fan; Zheng HaiXue
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Virology, 2023, 578, pp 141-153
Abstract

Long noncoding RNAs (lncRNAs) have been demonstrated to play key roles in various biological processes. However, the contributions of lncRNAs to Seneca Valley virus (SVV) infection and host defense remain largely unknown. In this study, differentially expressed lncRNAs and mRNAs in SVV-infected...

Author(s)
Dong JianGuo; Rao Dan; Chen MingRui; Zhao PanDeng; Huang Li
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2022, 8, March,
Abstract

The maintenance of viral protein homeostasis depends on the machinery of the infected host cells, giving us an insight into the interplay between host and virus. Accumulating evidence suggests that heat shock protein 60 (HSP60), as one molecular chaperone, is involved in regulating virus infection. ...

Author(s)
Tang JianLi; Abdullah, S. W.; Li PingHua; Wu Jin'en; Pei ChenChen; Mu SuYu; Wang YunLu; Sun ShiQi; Guo HuiChen
Publisher
American Society for Microbiology (ASM), Washington, D.C., USA
Citation
mBio, 2022, 13, 5,
Abstract

Seneca Valley virus (SVV) is a non-enveloped RNA virus and the only member of the Senecavirus A (SVA) species, in the Senecavirus genus, Picornaviridae family. SVV infection causes vesicular lesions in the oral cavity, snout and hooves of pigs. This infection is clinically indistinguishable from...

Author(s)
Bennett, B.; Urzúa-Encina, C.; Pardo-Roa, C.; Ariyama, N.; Lecocq, C.; Rivera, C.; Badía, C.; Suárez, P.; Agredo, M.; Aguayo, C.; Ávila, C.; Araya, H.; Pérez, P.; Berrios, F.; Agüero, B.; Mendieta, V.; Pituco, E. M.; Almeida, I. G. de; Medina, R.; Brito, B.; Johow, M.; Ramirez, V. N.
Publisher
Wiley, Berlin, Germany
Citation
Transboundary and Emerging Diseases, 2022, 69, 6, pp e3462-e3468
Abstract

Senecavirus A (SVA) infection in pigs can cause syndromes including blisters in the mouth, nose, hoof and coronary artery band, which seriously endangers the health of pigs. The VP1 protein is an important structural protein of SVA and can induce neutralizing antibodies in pigs. In this study, the...

Author(s)
Peng WanQing; Qian BingXu; Liao Kai; Dong YuHao; Xue Feng; Ni Bo; Xue QingHong; Dai JianJun
Publisher
Chinese Veterinary Science, Lanzhou, China
Citation
Chinese Veterinary Science / Zhongguo Shouyi Kexue, 2022, 52, 7, pp 867-874
Abstract

In order to improve the accuracy of laboratory diagnosis of porcine reproductive and respiratory syndrome Virus (PRRSV), the sequences of PRRSV strains in China in recent years were analyzed in this study. Specific primers were designed and synthesized for the main American and European genotype...

Author(s)
Wang FangZhou; Zhang Jing; Ma XueQing; Li PingHua; Bao HuiFang; Wang Jian; Zhao ZhiXun; Li JiaoYang; Li GuoXiu; Liu ZaiXin; Lu ZengJun; Zeng QiaoYing; Sun Pu
Publisher
Chinese Veterinary Science, Lanzhou, China
Citation
Chinese Veterinary Science / Zhongguo Shouyi Kexue, 2022, 52, 7, pp 805-814
Abstract

Since 2014, outbreaks of the Seneca Virus A (SVA) have occurred successively in Brazil, USA, China, Thailand and other countries. The scope of such epidemics is expanding. SVA has gradually become the focus of research and attention. Here, wes review the etiological studies related to SVA in the...

Author(s)
Tao Qian; Cao Fei; Peng KenAn; Zhu Ling; Xu ZhiWen
Publisher
Editorial Office of Chinese Journal of Virology, Beijing, China
Citation
Chinese Journal of Virology, 2022, 38, 2, pp 505-512
Abstract

Based on the induction of autophagy by Senecavirus A (SVA), we explored the role of VPZ protein in autophagy. A eukaryotic expression vector of VPZ, pcDNABl-VPZ was constructed, and transfected into PK-IS cells. The effect of VPZ protein on autophagy was evaluated by measuring expression of...

Author(s)
Wang Jing; Guo Yu; Zhao YunHuan; Gu WenYuan; Liu Tao; Zhai Gang; Zhang Shuai; Wang BingLei; Zuo YuZhu; Fan JingHui
Publisher
Editorial Office of Chinese Journal of Virology, Beijing, China
Citation
Chinese Journal of Virology, 2022, 38, 2, pp 431-438
Abstract

RNA interference (RNAi) is a major form of antiviral defense in host cells, and Ago2 and Dicer are the major proteins of RNAi. The Senecavirus A (SVA) is a reemerging virus, resulting in vesicular lesions in sows and a sharp decline in neonatal piglet production. In this study, CRISPR/Cas9...

Author(s)
Wu XiaoYan; Wang Shuo; Li Chen; Shi JianLi; Peng Zhe; Liu Chang; Han Hong; Ma YingRu; Zheng LiMei; Xu ShaoJian; Du Wei; Li Jun; Zhang Fan
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Cellular and Infection Microbiology, 2022, 12, April,
Abstract

Senecavirus A (SVA), an important member of the Picornaviridae family, causes vesicular disease in pigs. Here, we generated an EGFP-expressing recombinant SVA re-SVA-EGFP, which exhibited similar growth kinetics to its parental virus. The reporter SVA was used to study the role of pig ANTXR1...

Author(s)
Jia MeiYu; Sun MingXia; Tang YanDong; Zhang YuYuan; Wang HaiWei; Cai XueHui; Meng FanDan
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2022, 8, April,

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