Senecavirus A (SVA) is a newly emerging causative agent of vesicular diseases in swine characterized with wide genetic diversity and rapid evolution. The lack of immunologically active cell culture model impedes the study of SVA-specific innate immunity. Here, an immortalized porcine alveolar...

Long noncoding RNAs (lncRNAs) have been demonstrated to play key roles in various biological processes. However, the contributions of lncRNAs to Seneca Valley virus (SVV) infection and host defense remain largely unknown. In this study, differentially expressed lncRNAs and mRNAs in SVV-infected...

The maintenance of viral protein homeostasis depends on the machinery of the infected host cells, giving us an insight into the interplay between host and virus. Accumulating evidence suggests that heat shock protein 60 (HSP60), as one molecular chaperone, is involved in regulating virus infection. ...

Seneca Valley virus (SVV) is a non-enveloped RNA virus and the only member of the Senecavirus A (SVA) species, in the Senecavirus genus, Picornaviridae family. SVV infection causes vesicular lesions in the oral cavity, snout and hooves of pigs. This infection is clinically indistinguishable from...

Senecavirus A (SVA) infection in pigs can cause syndromes including blisters in the mouth, nose, hoof and coronary artery band, which seriously endangers the health of pigs. The VP1 protein is an important structural protein of SVA and can induce neutralizing antibodies in pigs. In this study, the...

In order to improve the accuracy of laboratory diagnosis of porcine reproductive and respiratory syndrome Virus (PRRSV), the sequences of PRRSV strains in China in recent years were analyzed in this study. Specific primers were designed and synthesized for the main American and European genotype...

Since 2014, outbreaks of the Seneca Virus A (SVA) have occurred successively in Brazil, USA, China, Thailand and other countries. The scope of such epidemics is expanding. SVA has gradually become the focus of research and attention. Here, wes review the etiological studies related to SVA in the...

Based on the induction of autophagy by Senecavirus A (SVA), we explored the role of VPZ protein in autophagy. A eukaryotic expression vector of VPZ, pcDNABl-VPZ was constructed, and transfected into PK-IS cells. The effect of VPZ protein on autophagy was evaluated by measuring expression of...

RNA interference (RNAi) is a major form of antiviral defense in host cells, and Ago2 and Dicer are the major proteins of RNAi. The Senecavirus A (SVA) is a reemerging virus, resulting in vesicular lesions in sows and a sharp decline in neonatal piglet production. In this study, CRISPR/Cas9...

Senecavirus A (SVA), an important member of the Picornaviridae family, causes vesicular disease in pigs. Here, we generated an EGFP-expressing recombinant SVA re-SVA-EGFP, which exhibited similar growth kinetics to its parental virus. The reporter SVA was used to study the role of pig ANTXR1...