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Abstract

Gaucher disease is caused by a deficiency of the enzyme glucocerebrosidase (GCase). Currently, enzyme-replacement therapy using recombinant GCase produced in mammalian cells is considered the most effective treatment. Plants are an attractive alternative host for recombinant protein production due...

Author(s)
Naphatsamon, U.; Ohashi, T.; Misaki, R.; Fujiyama, K.
Publisher
MDPI AG, Basel, Switzerland
Citation
International Journal of Molecular Sciences, 2018, 19, 7, pp 1972
Abstract

Xylan is a major hemicellulose in both primary and secondary walls of grass species. It consists of a linear backbone of β-1,4-linked xylosyl residues that are often substituted with monosaccharides and disaccharides. Xylosyl substitutions directly on the xylan backbone have not been reported in...

Author(s)
Zhong RuiQin; Cui DongTao; Phillips, D. R.; Ye ZhengHua
Publisher
Oxford University Press, Oxford, UK
Citation
Plant and Cell Physiology, 2018, 59, 3, pp 554-565
Abstract

Plants have emerged as one of the most attractive systems for producing human therapeutic proteins against viral diseases. These include diagnostic reagents, vaccines, and antibodies. This process is known as molecular biofarming. The objective of this study was to develop and evaluate tobacco and ...

Author(s)
Song IlChan; Park SolAh; Han, D.; Lee HaeKyung; An HyunJoo; Ko KiSung
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Horticulture, Environment and Biotechnology, 2018, 59, 2, pp 285-292
Abstract

We have previously demonstrated that the inducible plant viral vector (CMViva) in transgenic plant cell cultures can significantly improve the productivity of extracellular functional recombinant human alpha-1-antirypsin (rAAT) compared with either a common plant constitutive promoter (Cauliflower...

Author(s)
Huang TingKuo; Falk, B. W.; Dandekar, A. M.; McDonald, K. A.
Publisher
MDPI AG, Basel, Switzerland
Citation
International Journal of Molecular Sciences, 2018, 19, 6, pp 1561
Abstract

The global HIV epidemic continues to grow, with 1.8 million new infections occurring per year. In the absence of a cure and an AIDS vaccine, there is a pressing need to prevent new infections in order to curb the disease. Topical microbicides that block viral entry into human cells can potentially...

Author(s)
Hoelscher, M.; Tiller, N.; Teh, A. Y. H.; Wu GuoZhang; Ma, J. K. C.; Bock, R.
Publisher
Springer, Dordrecht, Netherlands
Citation
Plant Molecular Biology, 2018, 97, 4/5, pp 357-370
Abstract

Understanding the genetic and molecular bases of gene function is of increasing importance to harness their potential to produce plants with novel traits. One important objective is the improvement of plant productivity to meet future demands in food crop production. Gene function is mostly...

Author(s)
Cheuk, A.; Houde, M.
Publisher
American Society of Plant Biologists, Rockville, USA
Citation
Plant Physiology, 2018, 176, 3, pp 1919-1931
Abstract

Plant virus infectious clones are important tools with wide-ranging applications in different areas of biology and medicine. Their uses in plant pathology include the study of plant-virus interactions, and screening of germplasm as part of prebreeding programmes for virus resistance. They can also...

Author(s)
Brewer, H. C.; Hird, D. L.; Bailey, A. M.; Seal, S. E.; Foster, G. D.
Publisher
Wiley, Oxford, UK
Citation
Plant Biotechnology Journal, 2018, 16, 4, pp 832-843
Abstract

Main conclusion: We demonstrated successful overexpression of porcine reproductive and respiratory syndrome virus (PRRSV)-derived GP4D and GP5D antigenic proteins in Arabidopsis. Pigs immunized with transgenic plants expressing GP4D and GP5D proteins generated both humoral and cellular immune...

Author(s)
An ChulHan; Nazki, S.; Park SungChul; Jeong YuJeong; Lee JuHuck; Park SuJin; Khatun, A.; Kim WonIl; Park YounIl; Jeong JaeCheol; Kim ChaYoung
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Planta, 2018, 247, 4, pp 973-985
Abstract

Production of monoclonal antibodies and pharmaceutical proteins in transgenic plants has been the focus of many research efforts for close to 30 years. Use of plants as bioreactors reduces large-scale production costs and minimizes risk for human pathogens contamination. Stable nuclear...

Author(s)
Zvirin, T.; Magrisso, L.; Yaari, A.; Shoseyov, O.
Publisher
Springer US, Philadelphia, USA
Citation
Molecular Biotechnology, 2018, 60, 6, pp 387-395
Abstract

Plant cells constitute an attractive platform for production of recombinant proteins as more and more animal-free products and processes are desired. One of the challenges in using plant cells as production hosts has been the costs deriving from expensive culture medium components. In this work,...

Author(s)
Häkkinen, S. T.; Reuter, L.; Nuorti, N.; Joensuu, J. J.; Rischer, H.; Ritala, A.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Plant Science, 2018, 9, January, pp 45

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