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News Article

Study identifies key similarities between osteoarthritis in dogs and in humans

Review highlights the benefits of developing cross-species collaborations

An article published in Nature Reviews Rheumatology aims to raise awareness of spontaneous osteoarthritis (OA) in dogs and to stimulate discussion regarding its exploration under the One Health initiative to improve the health and well-being of both dogs and humans.

An international team of researchers, led by the Royal Veterinary College, identified key similarities between OA in dogs and in humans. They say similarities are partly due to the shared lifestyles and environments of dogs and humans, however their similar anatomies and disease physiology also contribute.

The researchers, who crossed various human and animal medicine disciplines, conducted a comprehensive review of literature related to OA, incorporating over 230 peer reviewed studies. It was found that both dogs and humans share the most common areas for the development of OA; the knee, hip, shoulder and elbows. The pain experienced by both dogs and humans with OA also has a common basis, leading the researchers to believe the neurophysiology of dogs and humans is also linked.

By compiling this knowledge into one paper, the researchers hope this review will lead to future collaborative research of OA by human and animal health experts.

The review was headed up by Dr Richard Meeson and Professor Andrew Pitsillides from the Royal Veterinary College, working in conjunction with bioengineers, human rheumatologists and veterinary research clinicians from the University College London, University of Portsmouth, the University of Edinburgh and Cornell University, USA.

Article: Spontaneous dog osteoarthritis — a One Medicine vision by Richard L. Meeson, Rory J. Todhunter, Gordon Blunn, George Nuki and Andrew A. Pitsillides, published in Nature Reviews Rheumatology, online 5 April 2019, doi: 10.1038/s41584-019-0202-1

Article details

  • Date
  • 17 April 2019
  • Source
  • Royal Veterinary College
  • Subject(s)
  • Dogs, Cats, and other Companion Animals