Therapeutic efficacy of two herbal preparations in induced hepatopathy in sheep.
Two formulations, one containing equal parts of Andrographis paniculata, Phyllanthus niruri and Solanum nigrum, and the second containing equal parts of Achyranthes aspera, Chichorium intybus and Berberis aristata were tried in sheep with liver disease induced with paracetamol. These drugs were given at doses of 1 g/kg body weight daily, orally in two doses for 10 days. Stretching of head and neck, staggering gait, muscle tremors, anorexia, diarrhoea, dullness, increase in pulse and respiration rates were the important clinical signs noted after paracetamol administration. Decrease in haemoglobin, packed cell volume, total erythrocyte count, lymphocyte count, blood glucose, total proteins, albumin and albumin:globulin ratio, and increase in total leukocyte count, neutrophil count, clotting time, serum cholesterol, triglyceride, total serum bilirubin, aspartate and alanine aminotransferases and bromsulfophthalein percent retention occurred following paracetamol treatment. These changes were reversed by both formulations with the first preparation more effective than the second.