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Global Health Hot Topics

Global Health Hot Topics

CABI's Global Health database comprehensively covers hot topics that matter.

We regularly select open access content to bring you key research and information on topics of interest. Allowing you to view key information FREE of charge.

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www.cabdirect.org

 

Diagnosing Tuberculosis

Early testing and diagnosis is a key part of the tuberculosis control strategy. Until recently diagnostic tests were time consuming , slow and expensive but DNA amplification methods have changed that. Two major new rapid methods are loop-mediated isothermal amplification (LAMP) and gene-Xpert MTB/RIF. Both are recommended by WHO as better than smear microscopy and are being tested in low resource settings around the world. The evidence suggests LAMP is more robust for low resource settings.

 

*Evaluation of the XpertMTB/RIF for the diagnosis of pulmonary tuberculosis among the patients attending DOTS Center Parsa District of Nepal.

 

*.The use of loop-mediated isothermal amplification (TB-LAMP) for the diagnosis of pulmonary tuberculosis: policy guidance.

 

*Assessment of Gene-Xpert MTB RIF program implementation and the challenges for enhanced tuberculosis diagnosis in Nigeria.

 

*Policy statement: automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system.

 

Mixed impact of Xpert® MTB/RIF on tuberculosis diagnosis in Cambodia.

 

Accuracy of LAMP-TB method for diagnosing tuberculosis in Haiti.

 

Molecular diagnosis of extrapulmonary tuberculosis and sensitivity to rifampicin with an automated real-time method.

 

Reassessment of the positive predictive value and specificity of Xpert MTB/RIF: a diagnostic accuracy study in the context of community-wide screening for tuberculosis.

 

**Diagnosis of multi-drug resistant tuberculosis mutations using Hain line probe assay and GeneXpert: a study done in Zimbabwe.

 

**Accuracy of a new rapid antigen detection test for pulmonary tuberculosis.

 

**Do the tuberculin skin test and the QuantiFERON-TB Gold in-tube test agree in detecting latent tuberculosis among high-risk contacts? A systematic review and meta-analysis.

 

*not in PubMed
** Fulltext hosted by CABI

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