The study was initiated to determine the anticancer activity of a novel compound isolated from the plant Mimosa pudica. The structure of the compound was identified as a derivative of myricetin having alkyl, hydroxy alkyl and methyl substitutions on the basis of spectral evidences (UV-vis, FT-IR, ...

Pancreatic cancer is the eighth leading cause of cancer death worldwide. Patients with pancreatic cancer are normally diagnosed at an advanced stage and present poor survival rate. Ovatodiolide (OV), a bioactive macrocyclic diterpenoid isolated from Anisomeles indica, showed cytotoxicity effects in ...

Triterpene saponins are secondary metabolites typical for higher plants. They possess a wide range of pharmaceutical and biological activities. These include anti-inflammatory, vasoprotective, expectorant, and antitumor properties. In particular, the ability of saponins to enhance the cytotoxicity...

Background: Propolis and Hypericum perforatum L. are natural products which contain many active compounds and have numerous beneficial effects, including an antitumor effect. Gliobmastoma multiforme (GBM) is a common primary brain tumor with poor prognosis and limited treatment options. In this...

Background: Recent studies report that inflammatory diseases of the large intestine are associated with colorectal cancer. Geijigajakyak Decoction (GJD) has antispasmodic and anti-inflammatory effects on the gastrointestinal tract. Thus, in light of the connection between chronic bowel inflammation ...

In order to screen and isolate the active constituents from invasive plant Macfadyena unguis-cati L. (Bignoniaceae), the anti-proliferative effects of SMMC7721, Bel7402 by different solvent extraction fractions of ethanol extracts of M. unguis-cati in vitro were studied by using MTT assay. The...

Many natural flavonoids have cytostatic and apoptotic properties; however, we little know whether the effect of synthetic 3-hydroxyflavone on metastasis and tumor growth of human osteosarcoma. Here, we tested the hypothesis that 3-hydroxyflavone suppresses human osteosarcoma cells metastasis and...

Ailanthus altissima (Mill.) Swingle (tree of heaven) is a fast-growing invasive species for Bulgaria and Europe and it belongs to the family Simaroubaceae. Carotenoid fraction from stem bark of Ailanthus altissima was isolated for the first time for this plant species, as well as lutein and...

Pectinatella magnifica, an invasive bryozoan, might significantly affect ecosystem balance due to its massive occurrence in many areas in Europe and other parts of the world. Biological and chemical analyses are needed to get complete information about the impact of the animal on the environment....

A new flavonoside, namely cirsimarin B (1), along with two known compounds cirsimarin (2) and acteoside (3), were isolated from the aerial parts of the invasive plant Macfadyena unguis-cati. Their structures were elucidated by extensive spectroscopic analyses (IR, FT-ICR-MS, 1D and 2D NMR) and by...