Camelpox virus (CMLV) is the closest known virus to variola virus. Here we report on the anti-CMLV activities of several acyclic nucleoside phosphonates (ANPs) related to cidofovir [(S)-1-(3-hydroxy-2-phosphonomethoxypropyl)cytosine (HPMPC; Vistide)] against two CMLV strains, CML1 and CML14....

We report that the anti-retroviral and anti-hepadnavirus molecules, adefovir, tenofovir and 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine (PMEDAP), efficiently eradicate the episomal form of Banana streak virus (BSV) from banana plants. Up to 90% of plants regenerated from BSV-infected highly...

Selected plants used in Rwandan traditional medicine for the treatment of infections and/or rheumatoid diseases were investigated for antiviral activity in vitro against human immunodeficiency virus type-1 (HIV-1). Of the 38 tested 80% ethanolic extracts, belonging to plants of 21 different...

Immunocompromised patients may have severe forms of infections. Since there is an increasing number of patients maintained under immunosuppressive therapy, we will be confronted with increasing frequency with these infectious problems. Effective treatments will be of great value. The case is...

Fifteen lambs were inoculated intracerebrally with visna maedi virus strain KV1772. Seven lambs were injected s.c. with 10 mg/kg PMEA 3 times a week starting 4 weeks after inoculation with visna maedi virus, when brain infection had been established; the other 8 lambs were controls. After 3 weeks...

To investigate the effects of phosphonate analog 9-(2-phosphonylmethoxyethyl) adenine (PMEA) on visna virus infection, 2 groups of 4 lambs each were inoculated intracerebrally with 10^6.3 TCID₅₀ of visna virus strain KV1772 and treated s.c. 3 times a week with PMEA at 10 and 25 mg/kg, respectively....