Anti-aging compounds in Latvian wild growing plant of Fallopia japonica.

Abstract

Fallopia japonica (Japanese knotweed) native to Japan is an aggressively invasive plant in the world, but also it contains a biological active natural compounds. Most important compounds of anti-aging by which can activate responsible gene sirtuin in nature is stilbenes trans-resveratrol (trans-3,4′,5-trihydroxystilbene), trans-piceid (resveratrol-3-β-mono-D-glucoside), flavonoid - butein (1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxy- phenyl)-2-propen-1-one), flavones - fisetin (3,3′,4′,7-tetrahydroxyflavone, 5-deoxyquercetin) and quercetin (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one). The aim of this study was to determine the anti-aging compounds in Latvian wild growing plant roots of Fallopia japonica. Before extraction roots of Fallopia japonica were convective dried at 60°C. For the extraction of the anti-aging compounds from Fallopia japonica roots the ethanol/water solution with the concentration 70% (v/v) was used. High performance liquid chromatography (HPLC) method was used for analysis of anti-aging compounds: resveratrol, piceid, butein, fisetin, and quercetin. The obtained results showed, that the main anti-aging compounds detected by HPLC method in Fallopia japonica were stilbenes: resveratrol and piceid. Flavone - fisetin was detected in significantly lower concentrations than resveratrol and piceid. The remaining compounds, quercetin and butein, were detected in trace amounts.