The most effective method of controlling larger grain borer is the use of synthetic pyrethroid insecticides such as permethrin and deltamethrin. However, these insecticides have proved to be ineffective against other storage pests, such as Sitophilus spp, which are found in the same pest complex as the invasive beetle. These other pests have proven more susceptible to organophosphorus pesticides. A combination of these and the synthetic pyrethroid insecticides provide an effective method for protecting farm-stored grain from pests, as long as high quantities are applied relatively frequently.
The predator Teretrius nigrescens has been indicated as a biocontrol solution to the larger grain borer. However, despite becoming quickly and easily established across large parts of Africa, it has not reduced the density of the pest by enough for it to be considered a biocontrol agent.
However, it does meet the impact criteria to be considered an important part of the integrated pest management system for dealing with the beetle.