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Lyme Disease

Lyme Disease

an Evidence-based Approach
Advances in Molecular and Cellular Microbiology

Edited by J Halperin, Professor of Medicine and Neurology, Mount Sinai School of Medicine, USA

August 2011 / Hardback / 296 Pages / 9781845938048 £85.00 / €110.00 / $160.00
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Main Description

Providing the medical practitioner with a broad scientific understanding, this book discusses the causative organism, its requisite ecosystem, disease epidemiology, host-Borrelia interactions, diagnostic testing, clinical manifestations, therapeutic options, and long term prognosis. It explicitly reviews both the basic biology of the infection and practical clinical aspects, linking the two to demonstrate what is and is not attributable to this infection. It is a broad and detailed guide for medics and researchers involved with diagnosing and treating Lyme, covering biology, epidemiology and therapeutics.


Researchers, students and clinicians in global health and infectious diseases.

Part I: Biological Substrate

1. Ticks: the Vectors of Lyme Disease

2. Borrelia: Biology of the Organism

3. Borrelia: Interactions with the Host Immune System

4. Laboratory Diagnostic Testing for Borrelia burgdorferi Infection

5. Persistence of Borrelia burgdorferi Infection aft er Antibiotic Treatment: What Can We Learn from Animal Models?

6. Global Epidemiology of Borrelia burgdorferi Infections

Part II: Clinical aspects

7. Antibiotic Therapy for Infection Caused by Borrelia burgdorferi Sensu Lato

8. Lyme Borreliosis in the UK and Ireland

9. Lyme Borreliosis: the European Perspective

10. Erythema Migrans

11. Cardiac Involvement

12. Rheumatological Involvement

13. Nervous System Involvement

14. Lyme Disease in Children

15. The Psychology of 'Post-Lyme Disease Syndrome' and 'Not Lyme'

16. Chronic Lyme Disease

17. Lyme Disease: the Great Controversy

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Halperin was educated at MIT and Harvard and received his clinical training at the University of Chicago and Massachusetts General Hospital. Currently Professor of Neurology and Medicine at New York's Mount Sinai School of Medicine, he began his career on the neurology faculty of SUNY Stony Brook, just as Lyme disease was being characterized. The multidisciplinary collaborative group there was able to substantially improve the knowledge base regarding this infection. An author or contributor to approximately 150 articles and chapters, Dr. Halperin lectures widely. He serves on the Guideline Development Subcommittee of the American Academy of Neurology, has been a long-standing examiner for the Neurology Board examination, and has been heavily involved in patient outcome improvement at Atlantic Health, the multihospital system in New Jersey where he now leads Neurosciences. Under his leadership, Overlook Hospital's Neuroscience program has rapidly become recognized as the state's best and busiest.

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