Abstract

This study was conducted to determine the fetotoxic effects of cypermethrin (CY) in rabbit does at low and high doses. 32 adult rabbit does were divided into 4 equal groups (A, B, C and D). Groups A, B and C were intraperitoneally treated with CY at dose rates of 25, 50 and 75 mg/kg body weight, whereas group D served as the control and given an equal volume of normal saline intraperitoneally. The clinical signs exhibited by the rabbits treated with CY included salivation, licking of different body parts, muscular tremors, ataxia and convulsions. A significant difference was observed in the numbers of corpus luteum (CL) and fetus, indicating the early embryonic death and post-implantation losses at the high dose. Microscopic changes were also observed in the ovaries and uteri of animals treated with CY.